Senior Specialist, Genetic Analysis

Exciting Opportunity at MSK: The Diagnostic Molecular Genetics Laboratory at Memorial Sloan Kettering Cancer Center is seeking a Senior Genetic Analysis Specialist to join a world-class clinical team focused on interpreting and classifying germline genetic variants that guide inherited cancer risk assessment and support patient care. This position offers the unique opportunity to work at the crossroads of clinical diagnostics, cuttingedge research, and advanced genomic analysis-making a meaningful impact in precision oncology.

Role Overview:

• Interpret and classify germline genetic variants identified through clinical next-generation sequencing (NGS) using AMP / ACMG guidelines with established genomic databases.

• Review NGS pipeline output for sample quality, accuracy, relevant genetic history, and sequencing artifacts; initiate confirmatory testing as needed.

• Collaborate closely with molecular pathologists, geneticists, genetic counselors, and bioinformaticians to draft and finalize clinical reports.

• Support laboratory operations under supervision, by contributing to workflow optimization, SOP development, and NYSDOH validation submissions.

• Train, mentor, and assess competency of peer analysts, new, and rotating staff in germline variant interpretation.

• Participate in translational research initiatives, data sharing efforts (e.g. ClinVar), and quality improvement projects.

• Assist with evaluating, testing, and integrating new variant analytical tools and databases into clinical workflows.

• Support regulatory inspections, as needed, to ensure clinical laboratory compliance with data security, clinical documentation, and HIPAA standards.

Key Qualifications:

• Master's degree in Human Genetics, Genetics, Genetic Counseling, Cancer Biology, Molecular Biology required.

• PhD in Human Genetics, Genetics, Cancer Biology or Molecular Biology is preferred.

• Comprehensive knowledge, and demonstrated proficiency towards interpreting germline variants in a clinical laboratory and/or cancer genetics setting.

• Strong foundation in human genetics and the molecular biology of cancer susceptibility genes.

• Experience with germline genetic databases and cancer predisposition variant analysis tools.

• Demonstrated ability to critically evaluate scientific literature and apply findings to clinical variant interpretation.

Core Skills:

• Advanced Analytical & Critical Thinking - Interprets complex genomic data and applies evidence-based reasoning to variant analysis.

• Molecular & Germline Genetics Knowledge - Experience with molecular lab workflows, germline cancer genetics, and clinical laboratory regulations.

• Genomic & Bioinformatics Knowledge - Experience with NGS, Sanger Sequencing and MLPA data interpretation, relevant clinical analysis tools, and bioinformatics software/databases.

• Expert Scientific Literacy - Ability to critically read, interpret, and apply findings from scientific literature to clinical practice and variant curation.

• Communication & Knowledge Sharing - Excellent written, verbal, and presentation skills; ability to train and collaborate effectively across multidisciplinary teams.

Additional Information:

• Location: Schwartz Building, 1250 First Avenue, New York, NY

• Schedule: Monday - Friday, 9 am - 5 pm

• Reports to: Pathology and Laboratory Medicine Supervisor, Molecular Diagnostic Lab

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