We use cookies. Find out more about it here. By continuing to browse this site you are agreeing to our use of cookies.
#alert
Back to search results
New

Principal Mechanical Engineer Project Manager

Genentech
United States, California, South San Francisco
Dec 10, 2025
The Position

Genentech is establishing a new Campus Development Team (CDT) to oversee the implementation of the Campus Vision Plan (CVP) for the South San Francisco campus. This Senior Principal Mechanical Engineer position provides single-point accountability for the successful end-to-end delivery of all Mechanical systems, with a primary focus on the complex laboratory and research environments within the gRED development. This role will also provide expertise for the supporting Vivarium, Utility Plant, and Electrical Distribution Hub as part of the CVP.

The Principal Mechanical Engineer works within a large, cross-functional project organization and serves as the primary technical liaison, coordinating the specific mechanical systems (HVAC, plumbing, fire protection, building controls, automation and energy management) and reliability needs of scientific and vivarium user groups into actionable engineering designs. This position is responsible for ensuring all mechanical systems are delivered safely, on schedule, within budget, and to the highest standards of quality, meeting the critical demands of a world-class R&D and animal care facility.

The Opportunity Responsibilities:

The responsibilities for this position may include, but are not limited to:

* Provides technical leadership and deep subject matter expertise for the mechanical engineering designs supporting gRED research laboratories, specialized vivarium spaces, and associated supporting projects.

* Actively leads the design and planning of HVAC, plumbing, fire protection, building controls, automation and energy management critical to laboratory operations and specialized vivarium environments.

* Coordinates with the Utility Master Plans to ensure that upgrades to critical mechanical infrastructure (including the Regional Utility Plant and Electrical Distribution Hub) directly support the reliability, redundancy and scalability required by the new lab facilities.

* Serves as a respected industry expert on laboratory mechanical design, engaging with the Roche/Genentech internal and industry external network to learn, influence, and collaborate on new technologies and best practices for gRED.

* Primary focus will be ensuring scientific user requirements are incorporated into robust technical solutions for the gRED project.

* Provide expert design guidance on HVAC, plumbing, fire protection, building controls, automation and energy management to labs and strategies for flexible 'plug-and-play' capabilities, and robust back-up systems to protect critical experiments, data, and animal life-support systems.

* Work closely with other technical leads to ensure seamless integration of HVAC, plumbing, fire protection, building controls, automation and energy management systems with lab-specific platforms like Building Automation Systems (BAS) and environmental monitoring systems.

* Serve as the mechanical SME in all design and user-group meetings, providing clear technical options analysis and advocating for designs that prioritize scientific workflow, flexibility, and safety.

* A key function of this role will also be to ensure all mechanical designs align with Roche/Genentech and site-specific standards, with a particular focus on standards governing laboratory design and vivarium operations.

* Coordinates the mechanical scope into a comprehensive strategy to address the technical needs across all aspects of the gRED project, from main infrastructure to the point-of-use in the lab.

* A portion of the Principal Mechanical Engineer's time will be spent supporting broad Design Engineering & Construction Services process improvement projects and LEAN initiatives, applying these principles to improve the lab design and delivery process.

* The Senior Principal Mechanical Engineer will be responsible for driving innovation in mechanical systems specifically for R&D environments, adopting technologies that improve lab flexibility, energy efficiency, and operational reliability.

* This role will participate in the development of a project-wide mechanical infrastructure strategy, in partnership with the Design team, to ensure the new gRED labs are adaptable for future scientific platforms and technologies, reducing total cost of ownership while maximizing uptime and research continuity.

* A key portion of the role is continuous learning, engagement with the Roche engineering network (technical experts within the Roche Global organization and other Roche sites) as well as outside industry organizations, including ASHRAE, ISPE and others.

Key Tasks:

* Project Planning and Coordination: Develop and maintain a comprehensive project plan, coordinating with architects, engineers, and contractors. Apply innovative thinking to proactively identify and mitigate risks, while monitoring progress via KPIs and reporting status to senior management.

* Budgeting and Resource Management: Support the development and management of the project budget, ensuring cost control and effective resource allocation. This role also supports all procurement activities, including vendor selection, contract negotiation, and material acquisitions.

* Stakeholder Management: Build and maintain strong relationships with internal and external stakeholders, fostering collaboration, transparency, and alignment. Serve as a trusted liaison, keeping all parties informed and engaged through regular meetings and progress reports.

* Team Leadership: Provide effective leadership by clarifying roles and fostering a collaborative, motivated work environment. Mentor and guide team members while also contributing strategic design and technical expertise to the facility's construction.

* Quality Control: Implement and enforce strict quality control measures to ensure compliance with industry standards and specifications..

Who You Are

Requirements:

* Bachelor's degree in Mechanical Engineering or equivalent.

* 15 years or more pharmaceutical technology experience in industry or academia after receiving their Bachelor's Degree, at least 8 of which involved mechanical system design, construction and\or commissioning and qualification activities.

* Working knowledge of ANSI / ASHRAE, NEMA, NFPA, EPA, and OSHA standards as well as relevant chemical industry specific standards and documentation (piping and instrumentation diagrams, process flow diagrams).

* Pharmaceutical GMP project mechanical design experience, LEED certification, experience in project management, LEAN / Six Sigma certification, and/or experience working in a campus environment highly desired, but not required.

* Must have excellent communication (written/verbal), presentation, leadership, interpersonal, collaborative, conflict resolution, and negotiating skills

* Excellent organization and planning skills.

* Advanced Microsoft Office and Google Suite skills.

* Exceptional teamwork and collaboration skills are essential to facilitate the work of cross-functional and interdepartmental teams.

* Must be dependable, provide attention to details, and execute proficiently in coordination tasks.

* Self-starter and ability to work with minimum or no supervision.

Relocation benefits are not available for this posting.

The expected salary range for this position based on the primary location of California is $168,10000 - $312,300 USD Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Applied = 0

(web-df9ddb7dc-vp9p8)