Scientist

Position Title: Scientist

Work Location: South San Francisco, CA, 94080

Assignment Duration: 06 months

Work Arrangement: Not specified

Position Summary: The Quantitative, Translational ADME Sciences (QTAS) department is seeking a highly motivated scientist to join the Biologics bioanalysis, characterization, and proteomics group.

Background & Context:

• The main function of this position is to develop and implement LC/MS (liquid chromatography/mass spectrometry)-based bioanalysis and in vitro characterization assays for novel biologics entities.
  
  Key Responsibilities:
• Operate and maintain LC/MS instruments to generate high-quality experimental data.
• Perform affinity purification of therapeutic proteins (including but not limited to monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices.
• Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks.
• Facilitate assay optimization and implementation to ensure laboratory capacity and data quality.
• Communicate data interpretation internally and externally.
  
  Qualification & Experience:
• Degree in chemistry, pharmacology or other related fields. BS with 5+ years or MS with 2+ years in a pharmaceutical industry setting with a focus on mass spectrometry.
• Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor.
• Prior industry experience in drug discovery/development is preferred.
• In-depth understanding of PK, TK and PK/PD studies and corresponding bioanalytical assays as well as in vitro characterization assays is highly desired.
• Hands-on experience with QQQ (SCIEX), qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers is highly desired.
• Hands-on experience with automated liquid handling systems is highly desired.
• Hands-on experience with oligonucleotide analysis is highly desired.
  
  Notes: N/A